Optical Biopsy of Amelanotic Melanoma with Raman and Autofluorescence Spectra Stimulated by 785 nm Laser Excitation

In this work, Raman and autofluorescence spectroscopy in the near-infrared region has been used for examining amelanotic melanoma as most dangerous type of malignant melanoma. There were 9 patients with melanoma, 60 pigmented 120 basal cell carcinoma enrolled study. We studied cases to differentiate them from (n = 120) 60) using portable setup laser excitation source at 785 nm low-cost spectrometer. The spectra different tumor classified projection on latent structure analysis 10-Fold cross-validation. results classification presented box-plot diagrams ROC analysis. obtained 0.53 0.88 AUCs distinguishing versus (1) (2) respectively based joint that allowed one diagnose true but no carcinoma.